In earlier commentaries, we presented slides and talks from C. Titus Brown, who is working on very big NGS libraries. How big? His 50TB library set would need 500TB server to run Velvet !! Yes, we are talking about 500TB RAM, not hard disk. We offered to rent him one such machine for only 5 T dollars/hour, but he came up with other ideas.
Note: What first two slides said is not at all clear to us. Please start from 3rd one.
We also found a video of him talking at a different conference on similar ideas -